Liver cancer is defined by an abnormal and uncontrolled growth of cells within the liver. These malignant cells progressively substitute the normal cells, collapsing the normal function of the liver, and invading other organs. There are two main types of liver cancer: Primary liver cancer, which appears from the cells that are normally located in the liver, and secondary liver cancer (also known as metastases), that is a cancer originated in other part of the body that sends the disrupted cells to the liver, where are implanted. The treatment of liver metastases depends on the type of primary cancer from which is originated and is mainly based in the use of pharmaceutical drugs commonly known as chemotherapy. Focusing on primary liver cancer, there are several types according to the type of cells that are altered. The most frequent, by far, is the hepatocellular carcinoma (HCC), a cancer derived from the main cell of the liver called hepatocyte. There are other types of primary liver cancer such as intrahepatic cholangiocarcinoma (derived from the biliary cells), sarcomas, etc., that should also be taken into account.