RESEARCH
LANDMARK PUBLICATIONS
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Regorafenib for patients with hepatocellular carcinoma who progressed on sorafenib treatment (RESORCE): a randomised, double-blind, placebo-controlled, phase 3 trial Bruix J, Qin S, Merle P, Granito A, Huang YH, Bodoky G, Pracht M, Yokosuka O, Rosmorduc O, Breder V, Gerolami R, Masi G, Ross PJ, Song T, Bronowicki JP, Ollivier-Hourmand I, Kudo M, Cheng AL, Llovet JM, Finn RS, LeBerre MA, Baumhauer A, Meinhardt G, Han G Lancet 2017;
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Early dermatologic adverse events predict better outcome in HCC patients treated with sorafenib Reig M, Torres F, Rodriguez-Lope C, Forner A, LLarch N, Rimola J, Darnell A, Ríos J, Ayuso C, Bruix J. Journal of Hepatology 2014;
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Postprogression survival of patients with advanced hepatocellular carcinoma: rationale for second-line trial design Reig M, Rimola J, Torres F, Darnell A, Rodriguez-Lope C, Forner A, Llarch N, Ríos J, Ayuso C, Bruix J Hepatology 2013;
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Prevalence of antibodies to hepatitis C virus in Spanish patients with hepatocellular carcinoma and hepatic cirrhosis J.Bruix, JM.Barrera, X.Calvet, G.Ercilla, J.Costa, JM.Sanchez Tapias, M.Ventura, M. Vall, M.Bruguera, C.Bru, R.Castillo, J.Rodés. Lancet 1989;:1004-1006.
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Natural history of hepatocellular carcinoma in Spain. A five year experience in 249 cases. X.Calvet, J.Bruix, C.Bru, P.Ginès, R.Vilana, M.Sole, MC.Ayuso, M.Bruguera, J.Rodés. J Hepatol 1990;10:311-317.
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Tumor size determines the efficacy of percutaneous ethanol injection for the treatment of small hepatocellular carcinoma. R.Vilana, J. Bruix, C.Bru, C.Ayuso, M. Sole, J. Rodés. Hepatology 1992;16:353-357.
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Treatment of small hepatocellular carcinoma in cirrhotic patients: a cohort study comparing surgical resection and percutaneous ethanol injection. A.Castells, J. Bruix, C. Bru,  J. Fuster, R.Vilana, M. Navasa, C. Ayuso, L. Boix, J. Visa, J. Rodés. Hepatology 1993;18:1121-1126.
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Treatment of hepatocellular carcinoma with tamoxifen. A Double-blind placebo controlled trial in 120 patients. A.Castells, J.Bruix, C. Brú, C.Ayuso, M. Roca, L. Boix, R. Vilana, J. Rodés. Gastroenterology 1995;109:917-922.
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Surgical resection of hepatocellular carcinoma in cirrhotic patients: Prognostic value of preoperative portal pressure. J. Bruix, A.Castells, J. Bosch, F.Feu, J. Fuster, J.C. Garcia Pagán, J. Visa, C. Brú, J. Rodés. Gastroenterology 1996;111:1018-1022.
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Liver transplantation for treatment of small hepatocellular carcinoma: the tumor-node- metastasis classification does not have prognostic power. JM. Llovet, J. Bruix, J. Fuster, A. Castells, JC. Garcia-Valdecasas, L.Grande, A. França, C. Brú, M.Navasa, MC. Ayuso, M. Solé, MI. Real, R. Vilana, A. Rimola, J. Visa, J. Rodés. Hepatology 1998;27:1572-1577.
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Transarterial embolization versus symptomatic treatment in patients with advanced hepatocellular carcinoma: results of a randomised, controled trial in a single institution. J. Bruix, JM. Llovet, A.Castells, X. Montanyá, C. Brú, MC. Ayuso, R. Vilana, J.Rodés. Hepatology 1998;29:173-183.
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Intention-to-treat analysis of surgical treatment for early hepatocellular carcinoma: resection versus trasplantation. JM. Llovet, J. Fuster, J. Bruix. Hepatology 1999;30:1434-1440.
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Natural history of untreated nonsurgical hepatocellular carcinoma: Rationale for the design and evaluation of therapeutic trials. JM. Llovet, J.Bustamante, A.Castells, R.Vilana, MC.Ayuso, M.Sala, C.Brú, J.Rodés, J.Bruix. Hepatology 1999;29:62-67.
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Living Donor Liver Transplantation for early Hepatocellular Carcinoma: A Life Expectancy and Cost-Effectiveness Perspective. F. Sarasin, P. Majno, JM. Llovet, J. Bruix, G. Mentha, A. Hadengue. Hepatology 2001;33:1073-1079
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Arterial embolization or chemoembolization versus symptomatic treatment in patients with unresectable hepatocellular carcinoma.: a randomised controlled trial. JM.Llovet,  MI.Real, X.  Montaña, R.  Planas, S. Coll, J.  Aponte, C. Ayuso, M. Sala,  J. Muchart, R. Solà, J. Rodés, J. Bruix for the Barcelona-Clínic-Liver Cancer Group. Lancet 2002;359:1734-1739.
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Systematic review of randomized trials for unresectable hepatocellular carcinoma: Chemoembolization improves survival. JM. Llovet and J. Bruix for the Barcelona-Clinic Liver Cancer Group. Hepatology 2003;37:429-442.
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MRI angiography is superior to triphasic helical CT for detection of small HCC prior liver transplantation. Comparison with pathologic correlation. M. Burrel, JM. Llovet, C. Ayuso, M. Sala, C. Iglesias, M. Solé, T. Caralt, JR. Ayuso, C. Brú, J. Bruix. Hepatology 2003;38:1034-1042.
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Orthotopic implantation of human hepatocellular carcinoma in mice: analysis of tumor progression and establishment of BCLC-9 cell line. C. Armengol,  G. Tarafa, L. Boix, M. Solé, R. Queralt, D. Costa, O. Bachs, J. Bruix, G. Capella. Cancer Res. 2003;10:2150-2157.
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Initial response to percutaneous ablation predicts survival in patients with hepatocellular carcinoma. M. Sala, JM. Llovet, R. Vilana, L. Bianchi, M Solé, C. Ayuso, C. Brú and J. Bruix for the Barcelona Clínic Liver Cancer Group. Hepatology 2004;40:1352-1360.
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High pathological risk of recurrence after surgical resection for hepatocellular carcinoma: an indication for salvage liver transplantation. M Sala, J Fuster, JM Llovet, M Navasa, M Sole, M Varela, F Pons, A Rimola, JC García-Valdecasas, C Bru, J Bruix; Barcelona Clinic Liver Cancer (BCLC) Group. Liver Transpl. 2004;10:1294-1300.
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A molecular signature to discriminate dysplastic nodules from early hepatocellular carcinoma in HCV cirrhosis. JM Llovet, Y Chen, E Wurmbach, S Roayaie, MI Fiel, M Schwartz, SN Thung, G Khitrov, W Zhang, A Villanueva, C Battiston, V Mazzaferro, J Bruix, S Waxman, SL Friedman. Gastroenterology 2006;131:1758-1767
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Chemoembolization of hepatocellular carcinoma with drug eluting beads: Efficacy and doxorubicin pharmacokinetics. M Varela, MI Real, M Burrel, A forner, M Sala, M Brunet, C Ayuso, L Castells, X Montaña, JM Llovet, J Bruix. J Hepatol. J Hepatol. 2007;46:474-481
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Diagnosis of hepatic nodules 20 mm or smaller in cirrhosis: Prospective validation of the noninvasive diagnosis criteria for hepatocellular carcinoma. A Forner, R Vilana, C Ayuso, L Bianchi, M Solé, JR Ayuso, L Boix, M Sala, M Varela, JM Llovet, C Brú, J Bruix. Hepatology 2008;47:97-104.
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Focal gains of VEGFA and molecular classification of hepatocellular carcinoma. DY Chiang, A Villanueva, Y Hoshida, J Peix, P Newell, B Minguez, AC LeBlanc, DJ Donovan, SN Thung, M Solé, V Tovar, C Alsinet, AH Ramos, J Barretina, S Roayaie, M Schwartz, S Waxman, J Bruix, V Mazzaferro, AH Ligon, V Najfeld, SL Friedman, WR Sellers, M Meyerson, JM Llovet. Cancer Res. 2008;68:6779-6788.
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Sorafenib in advanced hepatocellular carcinoma. JM Llovet, S Ricci, V Mazzaferro, P Hilgard, E Gane, JF Blanc, AC de Oliveira,  A Santoro, JL Raoul, A Forner, M Schwartz, C Porta, S Zeuzem, L Bolondi, TF Greten, PR Galle, JF Seitz, I Borbath, D Häussinger, T Giannaris, M Shan, M Moscovici, D Voliotis, J Bruix; SHARP Investigators Study Group. N Engl J Med. 2008;359:378-390
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Gene expression in fixed tissues and outcome in hepatocellular carcinoma. Y Hoshida, A Villanueva, M Kobayashi, J Peix, DY Chiang, A Camargo, S Gupta, J Moore, MJ Wrobel, J Lerner, M Reich, J, JA Chan, JN Glickman, K Ikeda, M Hashimoto, G Watanabe, MG Daidone, S Roayaie, M Schwartz, S Thung, HB Salvesen, S Gabriel, V Mazzaferro, J Bruix, SL Friedman, H Kumada, JM Llovet, TR Golub. N. England J Med 2008;359:1995-2004
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Predicting survival after liver transplantation in patients with hepatocellular carcinoma beyond the Milan criteria: a retrospective, exploratory analysis. V. Mazzaferro, JM Llovet, R Miceli, S Bhoori, M Schiavo, L Mariani, T Camerini, S Roayaie, ME Schwartz, GL Grazi, R Adam, P Neuhaus, M Salizzoni, J Bruix, A Forner, L De Carlis, U Cillo, AK Burroughs, R Troisi, M Rossi, GE Gerunda, J Lerut, J Belghiti, I Boin, J Gugenheim, F Rochling, B Van Hoek, P Majno; Metroticket Investigator Study Group. Lancet Oncol. 2009;10:35-43.
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Evaluation of tumor response after locoregional therapies in hepatocellular carcinoma: are response evaluation criteria in solid tumors reliable?. A Forner, C Ayuso, M Varela, J Rimola, AJ Hessheimer, CR de Lope, M Reig, L Bianchi, JM Llovet, J Bruix. Cancer 2009;115:616-623.
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Cholangiocarcinoma in cirrhosis: Absence of contrast washout in delayed phases by magnetic resonance imaging avoids misdiagnosis of hepatocellular carcinoma. J Rimola, A Forner, M Reig, R Vilana, CR de Lope, C Ayuso, J Bruix. Hepatology 2009;50:791-798
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A meta-analysis of survival rates of untreated patients in randomized clinical trials of hepatocellular carcinoma. G Cabibbo, M Enea, M Attanasio, J Bruix, A Craxi, C Cammà. Hepatology 2010;51:1274-1283.
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MicroRNA-Based classification of hepatocellular carcinoma and oncogenic role of miR-517a. S Toffanin, Y Hoshida, A Lachenmayer, A Villanueva, L Cabellos, B Minguez, R Savic, SC Ward, S Thung, DY Chiang, C Alsinet, V Tovar, S Rayaie, M Schwartz, J Bruix, S Waxman, SL Friedman, T Golub, V Mazzaferro, JM Llovet. Gastroenterology 2011;140:1618-1628.
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Maintenance Therapy With Peginterferon Alfa-2b Does Not Prevent Hepatocellular Carcinoma in Cirrhotic Patients With Chronic Hepatitis C. J Bruix, T Poymard, M Colombo, E Schiff, K Burak, EJ Healthcote, T Berq, JL Poo, CB Melllo, R Guenther, C Niederau, R Terg, P Bedossa, N Boparal LH Griffel, M Burroughs, CA Brass, JK Albrecht, Epic Study Group. Gastroenterology 2011;140:1990-1999.
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Combining clinical, pathology, and gene expression data to predict recurrence of hepatocellular carcinoma. A Villanueva, Y Hoshida, C Battiston, V Tovar, D Sia, C Alsinet, H Cornella, A liberzon, M Kobayashi, H Kumada, SN Thung, J Bruix, P Newell, C April, JB Fan, S Roayaie, V Mazzaferro, ME Schwartz, JM Llovet. Gastroenterology 2011;140:1501-1512.
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Plasma biomarkers as predictors of outcome in patients with advanced hepatocellular carcinoma. Llovet JM, Peña CE, Lathia CD, Shan M, Meinhardt G, Bruix J; SHARP Investigators Study Group. Clin Cancer Res. 2012;Apr 15;:18(8):2290-300.
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Efficacy and safety of sorafenib in patients with advanced hepatocellular carcinoma: subanalyses of a phase III trial. Bruix J, Raoul JL, Sherman M, Mazzaferro V, Bolondi L, Craxi A, Galle PR, Santoro A, Beaugrand M, Sangiovanni A, Porta C, Gerken G, Marrero JA, Nadel A, Shan M, Moscovici M, Voliotis D, Llovet JM. J Hepatol. 2012;Oct;:57(4):821-9.
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Integrative molecular analysis of intrahepatic cholangiocarcinoma reveals 2 classes that have different outcomes. Sia D, Hoshida Y, Villanueva A, Roayaie S, Ferrer J, Tabak B, Peix J, Sole M, Tovar V, Alsinet C, Cornella H, Klotzle B, Fan JB, Cotsoglou C, Thung SN, Fuster J, Waxman S, Garcia-Valdecasas JC, Bruix J, Schwartz ME, Beroukhim R, Mazzaferro V, Llovet JM. Gastroenterology. 2013;Apr;:144(4):829-40.
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Prognostic gene expression signature for patients with hepatitis C-related early-stage cirrhosis. Hoshida Y, Villanueva A, Sangiovanni A, Sole M, Hur C, Andersson KL, Chung RT, Gould J, Kojima K, Gupta S, Taylor B, Crenshaw A, Gabriel S, Minguez B, Iavarone M, Friedman SL, Colombo M, Llovet JM, Golub TR. Gastroenterology. 2013 ;May;:144(5):1024-30.
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A hepatocellular carcinoma 5-gene score associated with survival of patients after liver resection. Nault JC, De Reyniès A, Villanueva A, Calderaro J, Rebouissou S, Couchy G, Decaens T, Franco D, Imbeaud S, Rousseau F, Azoulay D, Saric J, Blanc JF, Balabaud C, Bioulac-Sage P, Laurent A, Laurent-Puig P, Llovet JM, Zucman-Rossi J. Gastroenterology. 2013;Jul;:145(1):176-87.
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Brivanib in patients with advanced hepatocellular carcinoma who were intolerant to sorafenib or for whom sorafenib failed: results from the randomized phase III BRISK-PS study. Llovet JM, Decaens T, Raoul JL, Boucher E, Kudo M, Chang C, Kang YK, Assenat E, Lim HY, Boige V, Mathurin P, Fartoux L, Lin DY, Bruix J, Poon RT, Sherman M, Blanc JF, Finn RS, Tak WY, Chao Y, Ezzeddine R, Liu D, Walters I, Park JW. J Clin Oncol. 2013;Oct 1;:31(28):3509-16.
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Postprogression survival of patients with advanced hepatocellular carcinoma: rationale for second-line trial design. Reig M, Rimola J, Torres F, Darnell A, Rodriguez-Lope C, Forner A, Llarch N, Ríos J, Ayuso C, Bruix J. Hepatology. 2013;Dec; :58(6):2023-31.
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UHRF1 Overexpression Drives DNA Hypomethylation and Hepatocellular Carcinoma. Mudbhary R, Hoshida Y, Chernyavskaya Y, Jacob V, Villanueva A, Fiel MI, Chen X, Kojima K, Thung S, Bronson RT, Lachenmayer A, Revill K, Alsinet C, Sachidanandam R, Desai A, Senbanerjee S, Ukomadu C, Llovet JM, Sadler KC. Cancer Cell. 2014;Feb 10;:25(2):196-209.
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